metformin and myostatin

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Kang MJ, Moon JW, Lee JO, Kim JH, Jung EJ, Kim SJ, Oh JY, Wu SW, Lee PR, Park SH, Kim HS. Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a. J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):605-620. doi: 10.1002/jcsm.12833. Epub 2021 Nov 2. PMID: 34725961; PMCID: PMC8818615.

Laksmi PW, Setiati S, Tamin TZ, Soewondo P, Rochmah W, Nafrialdi N, Prihartono J. Effect of Metformin on Handgrip Strength, Gait Speed, Myostatin Serum Level, and Health-related Quality of Life: A Double Blind Randomized Controlled Trial among Non-diabetic Pre-frail Elderly Patients. Acta Med Indones. 2017 Apr;49(2):118-127. PMID: 28790226.


Das AK, Yang QY, Fu X, Liang JF, Duarte MS, Zhu MJ, Trobridge GD, Du M. AMP-activated protein kinase stimulates myostatin expression in C2C12 cells. Biochem Biophys Res Commun. 2012 Oct 12;427(1):36-40. doi: 10.1016/j.bbrc.2012.08.138. Epub 2012 Sep 6. PMID: 22995402; PMCID: PMC3486733.

Ochi E, Hirose T, Hiranuma K, Min SK, Ishii N, Nakazato K. Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle. J Appl Physiol (1985). 2010 Feb;108(2):306-13. doi: 10.1152/japplphysiol.00278.2009. Epub 2009 Dec 3. PMID: 19959771.

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